SCHEMBL7410790

SCHEMBL7410790

COc1cc2c(cc1OC)C(c1ccc3c(Cl)cccc3c1)=NNC(=O)C2

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
CYP3A4 P08684 1/20 0.62
CYP2C9 P11712 1/20 0.62
MAPK1 P28482 1/20 0.62
CYP2C19 P33261 1/20 0.62
CRHBP P24387 1/20 0.43
CRHR2 Q13324 1/20 0.43
MAPK10 P53779 8/20 0.42
GRIA2 P42262 2/20 0.41
MAPK14 Q16539 3/20 0.40
MAPK9 P45984 2/20 0.40
CHEK1 O14757 1/20 0.40
DAPK3 O43293 1/20 0.40
JAK2 O60674 1/20 0.40
PRKD3 O94806 1/20 0.40
MAP4K4 O95819 1/20 0.40
PAK4 O96013 1/20 0.40
RET P07949 1/20 0.40
MET P08581 1/20 0.40
PDGFRA P16234 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7402313 0.85 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7408208 0.83 CYP1A2 (0.66) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7405387 0.81 CYP1A2 (0.78) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7409537 0.80 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407689 0.80 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7411882 0.79 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7511134 0.79 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL5488342 0.79 CYP1A2 (0.77) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407379 0.78 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407596 0.77 CYP1A2 (0.78) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002088096-A1 COMPOUNDS INHIBITING CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, PREPARATION AND USES THEREOF NEURO3D (FR) 2002-11-07 WO disclosed