Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 4/20 | 0.52 |
| ▸ | PARP1 | P09874 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664093 | 0.94 | PARP1 (0.58) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL665139 | 0.92 | PARP1 (0.60) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL665267 | 0.90 | PARP1 (0.59) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL664232 | 0.90 | PARP1 (0.57) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL665174 | 0.89 | PARP1 (0.56) | HTR2BPARP1PKM | |
| SCHEMBL663064 | 0.88 | PARP1 (0.60) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL666506 | 0.88 | PARP1 (0.57) | POLBHTR2BPARP1PKM | |
| SCHEMBL632795 | 0.85 | HTR2B (0.54) | POLBHTR2BPARP1KDM4EPKM | |
| SCHEMBL724921 | 0.82 | NPC1 (0.62) | POLBHTR2BKDM4E | |
| SCHEMBL6757201 | 0.82 | NPC1 (0.62) | POLBHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |