Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742438 | 1.00 | MAOA (0.39) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL2573934 | 0.88 | MAOA (0.41) | MAOAMAOBADRB2ALDH1A1HTT | |
| SCHEMBL923461 | 0.80 | MAOA (0.48) | MAOAMAOBKDM4EADRB2ALDH1A1 | |
| SCHEMBL1664848 | 0.78 | KMT2A (0.46) | KDM4EMEN1KMT2AALDH1A1HTT | |
| SCHEMBL5818358 | 0.77 | AKR1C1 (0.47) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL3716772 | 0.77 | MAOA (0.45) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL29024354 | 0.75 | CYP2C19 (0.48) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL11373445 | 0.75 | CYP2C19 (0.48) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL6585961 | 0.75 | CYP2C19 (0.48) | MAOAMAOBKDM4EMEN1KMT2A | |
| SCHEMBL31500148 | 0.74 | AOC3 (0.43) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431370-A1 | Monoacylated 1,2-diaminocycloalkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7935824-B2 | Ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | disclosed |