Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740859 | 1.00 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1RORC | |
| SCHEMBL743558 | 0.90 | CD274 (0.35) | RORCMTNR1AMTNR1B | |
| SCHEMBL743557 | 0.90 | CD274 (0.35) | RORCMTNR1AMTNR1B | |
| SCHEMBL739243 | 0.90 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1RORC | |
| SCHEMBL739242 | 0.90 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1RORC | |
| SCHEMBL738856 | 0.89 | HRH1 (0.43) | HRH1CYP2D6KCNH2CHRM1RORC | |
| SCHEMBL738855 | 0.89 | HRH1 (0.43) | HRH1CYP2D6KCNH2CHRM1RORC | |
| SCHEMBL763357 | 0.88 | HRH1 (0.43) | HRH1CYP2D6KCNH2CHRM1ALDH1A1 | |
| SCHEMBL763040 | 0.88 | MAPT (0.39) | HRH1CYP2D6KCNH2CHRM1ALDH1A1 | |
| SCHEMBL739861 | 0.87 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |