Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 3/20 | 0.36 |
| ▸ | CPT2 | P23786 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740643 | 0.90 | HRH1 (0.39) | HRH1CYP2D6CTSCKCNH2CHRM1 | |
| SCHEMBL740644 | 0.90 | HRH1 (0.39) | HRH1CYP2D6CTSCKCNH2CHRM1 | |
| SCHEMBL742247 | 0.89 | MAPT (0.39) | MAPTALDH1A1LMNARXFP1HRH1 | |
| SCHEMBL742248 | 0.89 | MAPT (0.39) | MAPTALDH1A1LMNARXFP1HRH1 | |
| SCHEMBL741495 | 0.89 | HRH1 (0.39) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL741496 | 0.89 | HRH1 (0.39) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL740858 | 0.88 | HRH1 (0.41) | ALDH1A1LMNAHRH1CYP2D6KCNH2 | |
| SCHEMBL740859 | 0.88 | HRH1 (0.41) | ALDH1A1LMNAHRH1CYP2D6KCNH2 | |
| SCHEMBL739243 | 0.86 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL739242 | 0.86 | HRH1 (0.41) | HRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |