Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28236498 | 0.82 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL4631199 | 0.78 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL1961849 | 0.78 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL2463271 | 0.76 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL28227519 | 0.74 | SSTR4 (0.46) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL28227466 | 0.73 | SSTR4 (0.47) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL28825591 | 0.73 | SSTR4 (0.45) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL28228207 | 0.72 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL8556232 | 0.72 | SSTR4 (0.37) | SLC6A2SLC6A4SLC6A3MLNRADRB2 | |
| SCHEMBL28048808 | 0.71 | TLR8 (0.39) | SLC6A2SLC6A4SLC6A3MLNRADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426106-A | Treatment of neurodegenerative diseases, schizophrenia, convulsions; selective non-competitive antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-20 | — | — | US | claimed |
| US-5420155-A | Treatment of nervous system disorders with derivatives of 4-hydroxy-2-(1H)-pyrrolones such as strokes, antiischemic agents or cardiovascular disorders | MERCK SHARP & DOHME LTD. (GB) | 1995-05-30 | — | — | US | claimed |
| US-5693640-A | Pyridazino-indole derivatives | MERCK, SHARP & DOHME, LTD. (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5614532-A | NERVOUS SYSTEM DISORDERS USING N-METHYLASPARTATE ANTAGONIST | MERCK, SHARP & DOHME LTD. (GB) | 1997-03-25 | — | — | US | disclosed |
| EP-0481676-B1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME (GB) | 1997-01-29 | — | — | EP | disclosed |
| US-5580877-A | Pyrazolo-quinoline derivatives for treating cerebral ischemia | MERCK SHARP & DOHME LTD. (GB) | 1996-12-03 | — | — | US | disclosed |
| US-5559125-A | NMDA AND AMPA RECEPTOR ANTAGONISTS, SCHIZOPHRENIA | MERCK, SHARP & DOHME LIMITED (GB) | 1996-09-24 | — | — | US | disclosed |
| US-5426106-A | Treatment of neurodegenerative diseases, schizophrenia, convulsions; selective non-competitive antagonists | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-20 | — | — | US | disclosed |
| US-5420155-A | Treatment of nervous system disorders with derivatives of 4-hydroxy-2-(1H)-pyrrolones such as strokes, antiischemic agents or cardiovascular disorders | MERCK SHARP & DOHME LTD. (GB) | 1995-05-30 | — | — | US | disclosed |
| EP-0620812-A1 | QUINOLONE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1994-10-26 | — | — | EP | disclosed |
| US-5348962-A | Nervous system disorders; schizophrenia | MERCK SHARPE & DOHME LTD. | 1994-09-20 | — | — | US | disclosed |
| WO-1993011115-A2 | QUINOLONE DERIVATIVES AND THEIR USE AS NMDA AND AMPA RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |
| EP-0481676-A1 | Hydroxyquinolone derivatives | MERCK SHARP & DOHME LTD. (GB) | 1992-04-22 | — | — | EP | disclosed |