Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL7412898 | 0.83 | TDP1 (0.49) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL27321459 | 0.81 | TSHR (0.55) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL16397415 | 0.81 | TDP1 (0.60) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4408694 | 0.81 | TDP1 (0.60) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL31377046 | 0.78 | TDP1 (0.53) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL7877955 | 0.78 | TDP1 (0.57) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL13930332 | 0.76 | L3MBTL1 (0.48) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL31016530 | 0.76 | L3MBTL1 (0.48) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL792508 | 0.76 | TSHR (0.56) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 | |
| Valeric Acid SCHEMBL27575451 | 0.75 | HSD17B10 (0.61) | TDP1L3MBTL1TSHRSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |