Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.58 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CASP1 | P29466 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29828584 | 0.96 | KLK7 (0.55) | KLK7KLK5CACNA1BPPARASMN1; SMN2 | |
| SCHEMBL4370045 | 0.90 | KLK5 (0.65) | KLK7KLK5CACNA1BPPARACTSS | |
| SCHEMBL31360771 | 0.89 | SMN1; SMN2 (0.49) | KLK7KLK5PPARASMN1; SMN2CTSS | |
| SCHEMBL29602353 | 0.89 | KLK7 (0.51) | KLK7KLK5PPARACTSSCASP1 | |
| SCHEMBL28713173 | 0.89 | KLK7 (0.51) | KLK7KLK5PPARACTSSCASP1 | |
| SCHEMBL9943561 | 0.87 | KLK5 (0.65) | KLK7KLK5CACNA1BPPARACTSS | |
| SCHEMBL10585294 | 0.87 | KLK5 (0.65) | KLK7KLK5CACNA1BPPARACTSS | |
| SCHEMBL9943562 | 0.87 | KLK5 (0.65) | KLK7KLK5CACNA1BPPARACTSS | |
| SCHEMBL12585497 | 0.87 | KLK5 (0.65) | KLK7KLK5CACNA1BPPARACTSS | |
| SCHEMBL17659960 | 0.86 | KLK5 (0.62) | KLK7KLK5CACNA1BPPARACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |