Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7415524 | 0.87 | TSHR (0.39) | DRD2SIGMAR1NPC1RAB9APIM1 | |
| SCHEMBL7408313 | 0.85 | NPC1 (0.52) | HRH4EGLN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7411450 | 0.77 | PARP1 (0.39) | HRH4PARP1 | |
| SCHEMBL7409815 | 0.73 | PARP1 (0.60) | PARP1 | |
| SCHEMBL5621923 | 0.73 | PARP1 (0.67) | PARP1 | |
| SCHEMBL6869369 | 0.71 | PARP1 (0.49) | PARP1 | |
| SCHEMBL5621386 | 0.70 | PARP1 (0.62) | PARP1 | |
| SCHEMBL11198421 | 0.68 | HRH4 (0.58) | HRH4NPC1RAB9APIM1PARP1 | |
| SCHEMBL6757251 | 0.66 | CBFB (0.44) | HRH4EGLN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9847093 | 0.66 | CBFB (0.46) | EGLN1NPC1RAB9ASMN1; SMN2CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |