Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409265 | 0.87 | HRH4 (0.42) | DRD2SIGMAR1PARP1NPC1RAB9A | |
| SCHEMBL7410146 | 0.78 | PARP1 (0.61) | DRD2PARP1PARP2 | |
| SCHEMBL7409701 | 0.75 | PARP1 (0.61) | DRD2PARP1PARP2 | |
| SCHEMBL5621923 | 0.74 | PARP1 (0.67) | PARP1PARP2 | |
| SCHEMBL7410700 | 0.73 | PARP1 (0.57) | DRD2PARP1PARP2 | |
| SCHEMBL7411450 | 0.72 | PARP1 (0.39) | PARP1PARP2 | |
| SCHEMBL7408313 | 0.72 | NPC1 (0.52) | MEN1KMT2APARP1NPC1RAB9A | |
| SCHEMBL6869369 | 0.71 | PARP1 (0.49) | PARP1PARP2 | |
| SCHEMBL5621386 | 0.71 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL10299142 | 0.70 | ADRB2 (0.44) | PARP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |