Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CREB1 | P16220 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | GAPDH | P04406 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954004 | 0.90 | SMN1; SMN2 (0.41) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL6954754 | 0.80 | SMN1; SMN2 (0.40) | ABCB1SMN1; SMN2L3MBTL1POLBMAPT | |
| SCHEMBL6955768 | 0.78 | SMN1; SMN2 (0.44) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL6965574 | 0.77 | ALDH1A1 (0.42) | SMN1; SMN2MAPTKDM4EUSP2ALDH1A1 | |
| SCHEMBL6953958 | 0.75 | ABCB1 (0.38) | ABCB1L3MBTL1MAPTCYP1A1CYP1A2 | |
| SCHEMBL6956690 | 0.74 | SMN1; SMN2 (0.43) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL6173258 | 0.73 | CYP2C9 (0.56) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL7367968 | 0.73 | SMN1; SMN2 (0.44) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL6963486 | 0.72 | ABCB1 (0.38) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 | |
| SCHEMBL6964293 | 0.71 | SMN1; SMN2 (0.42) | ABCB1SMN1; SMN2L3MBTL1POLBCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |