SCHEMBL7409774

SCHEMBL7409774

COc1nsc(NC(=O)[C@H](Cc2ccccc2)NC(=O)OCc2ccccc2)n1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CTSL P07711 3/20 0.54
CTSB P07858 1/20 0.54
CTSS P25774 1/20 0.54
CTSK P43235 1/20 0.54
ALDH1A1 P00352 1/20 0.53
ALOX15 P16050 1/20 0.53
TACR1 P25103 2/20 0.53
HDAC8 Q9BY41 1/20 0.52
F2 P00734 1/20 0.50
PRSS1 P07477 1/20 0.50
PRSS2 P07478 1/20 0.50
PRSS3 P35030 1/20 0.50
KDM1A O60341 3/20 0.49
MAOA P21397 2/20 0.49
KDM1B Q8NB78 1/20 0.49
RCOR1 Q9UKL0 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7450374 0.93 CTSL (0.50) CTSLCTSBCTSSCTSKALDH1A1
SCHEMBL27493280 0.93 CTSL (0.50) CTSLCTSBCTSSCTSKALDH1A1
SCHEMBL7600349 0.86 CTSL (0.57) CTSLCTSBCTSSCTSKTACR1
SCHEMBL11184923 0.79 TACR1 (0.57) CTSLCTSBCTSSCTSKTACR1
SCHEMBL7640967 0.78 ATM (0.47) ALDH1A1ALOX15
SCHEMBL4154649 0.76 HDAC8 (0.80) CTSLCTSBCTSSCTSKHDAC8
SCHEMBL13768104 0.76 CTSL (0.61) CTSLCTSBCTSSCTSKALDH1A1
SCHEMBL7370634 0.76 HDAC8 (0.73) CTSLCTSBCTSSCTSKTACR1
SCHEMBL7443382 0.76 TACR1 (0.53) CTSLCTSBCTSSCTSKTACR1
SCHEMBL7038484 0.75 HDAC8 (0.78) CTSLCTSBCTSSCTSKHDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6468977-B1 COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS APOTEX INC. (CA) 2002-10-22 US claimed
WO-2001090095-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2001-11-29 WO claimed
US-6162791-A Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes APOTEX INC. (CA) 2000-12-19 US claimed
EP-1058690-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 2000-12-13 EP claimed
WO-1999045027-A1 THIADIAZOLE COMPOUNDS USEFUL AS INHIBITORS OF CYSTEINE ACTIVITY DEPENDENT ENZYMES APOTEX INC. (CA) 1999-09-10 WO claimed
US-6468977-B1 COMPOUNDS USEFUL IN TREATMENT TREATMENT OF DISORDER AND/OR DISEASE CAUSED BY ACTIVITY OF ENZYMES SUCH AS HUMAN RHINOVIRUS 3C PROTEASE, TRANSGLUTAMINASE AND CATHEPSINS APOTEX INC. (CA) 2002-10-22 US disclosed
US-6162791-A Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes APOTEX INC. (CA) 2000-12-19 US disclosed