Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30167310 | 0.88 | KMT2A (0.43) | KMT2ATAS1R3TAS1R1AOC3MTNR1A | |
| SCHEMBL7311626 | 0.88 | KMT2A (0.43) | KMT2ATAS1R3TAS1R1AOC3MTNR1A | |
| SCHEMBL29061992 | 0.87 | KMT2A (0.49) | KMT2AAOC3MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL7652207 | 0.87 | KMT2A (0.49) | KMT2AAOC3MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL9230531 | 0.83 | KMT2A (0.51) | KMT2AAOC3MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL9230540 | 0.83 | KMT2A (0.48) | KMT2AAOC3MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL27772300 | 0.82 | CTSS (0.44) | KMT2A | |
| SCHEMBL7661916 | 0.82 | CASR (0.50) | KMT2AMTNR1AMTNR1BCASRPBRM1 | |
| SCHEMBL21708793 | 0.82 | KMT2A (0.52) | KMT2ATAS1R3TAS1R1MTNR1AMTNR1B | |
| SCHEMBL3827110 | 0.81 | AOC3 (0.44) | KMT2AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101842361-B | Pyrazinone derivatives and their use in the treatment of lung diseases | ASTRAZENECA AB | 2013-06-05 | — | — | CN | disclosed |
| CN-101842361-A | Pyrazinone derivatives and their use in the treatment of lung diseases | ASTRAZENECA AB | 2010-09-22 | — | — | CN | disclosed |
| US-6358973-B1 | FOR THERAPY OF ALLERGIC OR INFLAMMATORY DISEASE | ZAMBON GROUP S.P.A. (IT) | 2002-03-19 | — | — | US | disclosed |
| EP-1121353-A1 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000021947-A1 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-04-20 | — | — | WO | disclosed |