Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | ECE1 | P42892 | 4/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | MMP7 | P09237 | 2/20 | 0.44 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412819 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL7410315 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL7412806 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL9242659 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL7410319 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL7412810 | 1.00 | ACE (0.46) | ACEECE1MMP1MMP3MMP7 | |
| SCHEMBL7411845 | 0.87 | MMP1 (0.43) | ACEMMP1MMP3MMP7SSTR3 | |
| SCHEMBL7411850 | 0.87 | MMP1 (0.43) | ACEMMP1MMP3MMP7SSTR3 | |
| SCHEMBL7413406 | 0.87 | MMP1 (0.43) | ACEMMP1MMP3MMP7SSTR3 | |
| SCHEMBL7411840 | 0.87 | MMP1 (0.43) | ACEMMP1MMP3MMP7SSTR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | claimed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | claimed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | claimed |
| US-5414017-A | Cardiovascular agents | E. R. SQUIBB & SONS, INC. (US) | 1995-05-09 | — | — | US | disclosed |
| EP-0449523-B1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | SQUIBB & SONS INC (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5223516-A | Endopeptidase inhibitors | E. R. SQUIBB & SONS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| EP-0449523-A1 | Mercapto- or acylthio-trifluoromethyl amide derivatives and their use | E.R. SQUIBB & SONS, INC. (US) | 1991-10-02 | — | — | EP | disclosed |