Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 10/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | THPO | P40225 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7417162 | 0.99 | SIGMAR1 (0.97) | SIGMAR1CYP2D6CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8320910 | 0.91 | SIGMAR1 (0.83) | SIGMAR1CYP2D6CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8320904 | 0.91 | SIGMAR1 (0.83) | SIGMAR1CYP2D6CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6724194 | 0.79 | SIGMAR1 (1.00) | SIGMAR1CYP2D6TP53TSHRTHPO | |
| Hydrochloric Acid SCHEMBL7415155 | 0.78 | SIGMAR1 (0.97) | SIGMAR1CYP2D6TP53TSHRTHPO | |
| SCHEMBL6582932 | 0.76 | SIGMAR1 (0.61) | SIGMAR1CYP2D6CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6719529 | 0.75 | SIGMAR1 (1.00) | SIGMAR1CYP2D6TP53TSHRTHPO | |
| Hydrochloric Acid SCHEMBL7412585 | 0.74 | SIGMAR1 (0.97) | SIGMAR1CYP2D6TP53TSHRTHPO | |
| SCHEMBL7620398 | 0.73 | SIGMAR1 (0.65) | SIGMAR1CYP2C9TSHR | |
| SCHEMBL28821130 | 0.73 | SIGMAR1 (0.61) | SIGMAR1CYP2D6CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3298875-B2 | — | — | 2002-07-08 | — | — | JP | claimed |
| US-5798390-A | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) | 1998-08-25 | — | — | US | claimed |
| US-5336689-A | Treating diseases of the nervous system; neuroprotective | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON (US) | 1994-08-09 | — | — | US | claimed |
| EP-0517852-A4 | — | — | 1994-03-02 | — | — | EP | claimed |
| US-5262568-A | Neuroprotective compounds, high binding affinity for phencyclidine, nervous system disorders | STATE OF OREGON (US) | 1993-11-16 | — | — | US | claimed |
| EP-0517852-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1992-12-16 | — | — | EP | claimed |
| WO-1991012797-A1 | TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) | 1991-09-05 | — | — | WO | claimed |