Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | TLR4 | O00206 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409152 | 0.88 | ADRB2 (0.42) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7410151 | 0.81 | ADRB2 (0.51) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7411916 | 0.81 | ADRB2 (0.63) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7413321 | 0.81 | ADRB2 (0.48) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7412052 | 0.79 | ADRB2 (0.48) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7410117 | 0.79 | ADRB2 (0.51) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7411213 | 0.79 | ADRB2 (0.53) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7410486 | 0.79 | ADRB2 (0.54) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7407189 | 0.78 | ADRB2 (0.49) | ADRB2ADRB1ADRB3OPRM1OPRK1 | |
| SCHEMBL7416746 | 0.77 | ADRB2 (0.44) | ADRB2ADRB1ADRB3OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4503067-A | HYPOTENSIVE, ANGINA PECTORIS | BOEHRINGER MANNHEIM GMBH (DE) | 1985-03-05 | — | — | US | disclosed |
| EP-0004920-B1 | DERIVATIVES OF CARBAZOLYL-4-OXYPROPANOLAMINE, METHODS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-08-05 | — | — | EP | disclosed |
| EP-0004920-A1 | Derivatives of carbazolyl-4-oxypropanolamine, methods for their preparation and medicines containing them | Roche Diagnostics GmbH (DE) | 1979-10-31 | — | — | EP | disclosed |