SCHEMBL7410641

SCHEMBL7410641

Cc1ccc(OC[C@H]2CCN2C)c(NC(=O)c2nc(C)cc(NC=O)c2OC[C@@H]2CCN2C)n1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GPR6 P46095 6/20 0.36
CHRNB4 P30926 4/20 0.34
CHRNA3 P32297 4/20 0.34
MCHR1 Q99705 2/20 0.34
CHRNB2 P17787 3/20 0.34
CHRNA4 P43681 3/20 0.34
CHRNB1 P11230 2/20 0.34
CHRNB3 Q05901 2/20 0.34
HCRTR2 O43614 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7410190 0.95 CHRNB4 (0.41) CHRNB4CHRNA3MCHR1CHRNB2CHRNA4
SCHEMBL7404785 0.85 GPR6 (0.35) GPR6CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7414106 0.82 CHRNB4 (0.40) GPR6CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7404861 0.78 CHRNB4 (0.43) GPR6CHRNB4CHRNA3CHRNB2CHRNA4
SCHEMBL7452699 0.67 CHRNB4 (0.47) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1
SCHEMBL7412172 0.66 CHRNA3 (0.49) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1
SCHEMBL7408945 0.66 CHRNA3 (0.49) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1
SCHEMBL7454988 0.66 CHRNA3 (0.39) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1
SCHEMBL7408472 0.65 CHRNB4 (0.42) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1
SCHEMBL8150132 0.63 CHRNA3 (0.40) CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed