Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.46 |
| ▸ | F7 | P08709 | 3/20 | 0.44 |
| ▸ | F3 | P13726 | 3/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409102 | 0.87 | F2 (0.48) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL3238624 | 0.80 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7374219 | 0.79 | F2 (0.53) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23461145 | 0.79 | F2 (0.65) | F2PRSS1F7F3PRSS2 | |
| SCHEMBL7410701 | 0.77 | TP53 (0.37) | — | |
| SCHEMBL23460571 | 0.75 | F2 (0.49) | F2PRSS1F7F3PRSS2 | |
| SCHEMBL23460555 | 0.74 | F2 (0.58) | F2PRSS1F7F3PRSS2 | |
| SCHEMBL23461147 | 0.73 | F2 (0.56) | F2PRSS1F7F3 | |
| SCHEMBL23461166 | 0.72 | F2 (0.55) | F2PRSS1F7F3PRSS2 | |
| SCHEMBL23460927 | 0.72 | F2 (0.53) | F2PRSS1F7F3PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079835-A4 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-29 | — | — | EP | disclosed |
| EP-1079835-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6147078-A | SERINE PROTEASE INHIBITOR | MERCK & CO., INC. (US) | 2000-11-14 | — | — | US | disclosed |
| WO-1999059591-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-11-25 | — | — | WO | disclosed |