Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410696 | 0.87 | F2 (0.48) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5474694 | 0.84 | F2 (0.64) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7409106 | 0.81 | MEN1 (0.41) | MEN1KMT2A | |
| SCHEMBL23460834 | 0.74 | MEN1 (0.47) | F2PRSS1MEN1KMT2A | |
| SCHEMBL23474187 | 0.73 | F2 (0.48) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL23474317 | 0.73 | F2 (0.55) | F2PRSS1MEN1KMT2A | |
| SCHEMBL3238624 | 0.72 | F2 (0.70) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7158554 | 0.72 | F2 (0.63) | F2PRSS1 | |
| SCHEMBL23474307 | 0.71 | F2 (0.45) | F2PRSS1PRSS2PRSS3MEN1 | |
| SCHEMBL31742245 | 0.71 | F2 (0.70) | F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079835-A4 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-29 | — | — | EP | disclosed |
| EP-1079835-A1 | PYRAZINONE THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-03-07 | — | — | EP | disclosed |
| US-6147078-A | SERINE PROTEASE INHIBITOR | MERCK & CO., INC. (US) | 2000-11-14 | — | — | US | disclosed |
| WO-1999059591-A1 | PYRAZINONE THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 1999-11-25 | — | — | WO | disclosed |