SCHEMBL7410710

SCHEMBL7410710

CC(=O)Nc1cc(OC[C@@H]2CCN2C)cnc1Cl

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 4/20 0.53
CHRNB4 P30926 3/20 0.49
CHRNA7 P36544 1/20 0.49
CHRNB2 P17787 3/20 0.46
CHRNA4 P43681 3/20 0.46
CHRNB1 P11230 1/20 0.46
CHRNB3 Q05901 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7828705 1.00 CHRNA3 (0.53) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7832217 0.93 CHRNB4 (0.58) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7818168 0.93 CHRNB4 (0.58) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7816950 0.86 CHRNA3 (0.47) CHRNA3CHRNB4CHRNB2CHRNA4
SCHEMBL7414718 0.86 CHRNA3 (0.47) CHRNA3CHRNB4CHRNB2CHRNA4
SCHEMBL7828932 0.82 CHRNA3 (0.56) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7827407 0.82 CHRNA3 (0.56) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL8150134 0.82 CHRNA3 (0.51) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6586429 0.81 CHRNA3 (0.50) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL8150132 0.80 CHRNA3 (0.40) CHRNA3CHRNB4CHRNB2CHRNA4CHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0846114-B1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-12-05 EP claimed
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP claimed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO claimed
EP-0846114-B1 3-PYRIDYLOXYALKYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2001-12-05 EP disclosed