Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 7/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741084 | 1.00 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL15304583 | 1.00 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL3183936 | 0.89 | MAOB (0.44) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL1091835 | 0.89 | MAOB (0.44) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL1091768 | 0.89 | MAOB (0.44) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL1091288 | 0.89 | MAOB (0.44) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL3183943 | 0.89 | MAOB (0.44) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL220637 | 0.89 | MAOB (0.46) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL220638 | 0.89 | MAOB (0.46) | SLC6A2SLC6A4SLC6A3MAOBMAOA | |
| SCHEMBL14687597 | 0.89 | MAOB (0.43) | MAOBMAOAGPR119CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697721-B2 | Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors | ANIONA APS (DK) | 2014-04-15 | — | — | US | disclosed |
| EP-2430020-B1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | ANIONA APS (DK) | 2013-10-09 | — | — | EP | disclosed |
| US-20120088789-A1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2012-04-12 | — | — | US | disclosed |
| EP-2430020-A1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NeuroSearch A/S (DK) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130620-A1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088789-A1 | CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, SLC18A1 | SLC6A2 2/4885SLC6A4 7/4885SLC6A3 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.