Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411447 | 1.00 | HDAC8 (0.43) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL10021382 | 0.83 | HDAC8 (0.48) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL4426389 | 0.83 | HDAC8 (0.48) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL4426383 | 0.83 | HDAC8 (0.48) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL7412483 | 0.83 | HDAC4 (0.41) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL7412488 | 0.83 | HDAC4 (0.41) | HDAC8FFAR1LMNACYP1A2RAB9A | |
| SCHEMBL7413164 | 0.81 | EGLN1 (0.36) | HDAC8MAP4K4EGLN1GCGR | |
| SCHEMBL7413167 | 0.81 | EGLN1 (0.36) | HDAC8MAP4K4EGLN1GCGR | |
| SCHEMBL7409322 | 0.80 | EGLN1 (0.45) | LMNARAB9ASMN1; SMN2MAP4K4EGLN1 | |
| SCHEMBL7409324 | 0.80 | EGLN1 (0.45) | LMNARAB9ASMN1; SMN2MAP4K4EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | claimed |
| US-6399612-B1 | 4-(4-(5-CHLORO-THIOPHEN-2-YL)-PHENYL)-4-OXO-BUTYRIC ACID; GELATINASE A (MMP-2), COLLAGENASE-3 (MMP-13), AND STROMELYSIN-1 (MMP-3) | WARNER-LAMBERT COMPANY | 2002-06-04 | — | — | US | disclosed |
| WO-1999018079-A1 | HETEROARYL BUTYRIC ACIDS AND THEIR DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |