Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.54 |
| ▸ | DRD4 | P21917 | 7/20 | 0.54 |
| ▸ | DRD3 | P35462 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aplindore SCHEMBL119499 | 0.83 | DRD2 (0.68) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| Aplindore SCHEMBL3192098 | 0.83 | DRD2 (0.68) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| Aplindore SCHEMBL29359212 | 0.83 | DRD2 (0.68) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5957116 | 0.81 | DRD2 (0.52) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5957050 | 0.81 | DRD2 (0.52) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5957135 | 0.80 | DRD2 (0.51) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5957109 | 0.78 | DRD2 (0.58) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| SCHEMBL5957062 | 0.77 | DRD2 (0.52) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| Aplindore SCHEMBL29470967 | 0.77 | DRD2 (0.60) | DRD2DRD4DRD3ALDH1A1MEN1 | |
| Aplindore SCHEMBL5954695 | 0.77 | DRD2 (0.60) | DRD2DRD4DRD3ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350773-B1 | Therapeutic combinations of (S)-2-(benzylamino-methyl)-2,3,8,9,-tetrahydro 7H-1,4-dioxino{2,3-e}indol-8-one and neuroleptics for the treatment or prevention of psychotic disorders | AMERICAN HOME PRODUCTS CORPORATION | 2002-02-26 | — | — | US | claimed |