Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.65 |
| ▸ | USP2 | O75604 | 3/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | RECQL | P46063 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 4/20 | 0.56 |
| ▸ | THRA | P10827 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154805 | 0.94 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL31263758 | 0.94 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL274387 | 0.94 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL274388 | 0.94 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL12799629 | 0.83 | ALOX15 (0.56) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL9952434 | 0.81 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL9952430 | 0.81 | SLC7A5 (0.73) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL12656312 | 0.81 | SLC1A1 (0.59) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL31734663 | 0.81 | SLC7A5 (0.62) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| SCHEMBL2778612 | 0.81 | SLC7A5 (0.62) | SLC7A5USP2PTGS1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691311-A | Methods for coating invasive devices with inhibitors of thrombin | BIOGEN, INC. (US) | 1997-11-25 | — | — | US | disclosed |
| US-5656600-A | MODIFIED POLYPEPTIDES | CORVAS INTERNATIONAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| EP-0489070-B1 | NOVEL INHIBITORS OF THROMBIN | BIOGEN INC (US) | 1996-04-24 | — | — | EP | disclosed |
| US-5433940-A | Synthetic molecules mimic action of hirudin by binding to both the low affinity anion-binding exosite and the catalytic site of thrombin | BIOGEN, INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5196404-A | Hirudin mimic, polypeptide, hirulog; bivalirudin FDA Orange book listed patent | BIOGEN, INC. (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0489070-A1 | NOVEL INHIBITORS OF THROMBIN. | BIOGEN INC (US) | 1992-06-10 | — | — | EP | disclosed |
| WO-1991002750-A1 | NOVEL INHIBITORS OF THROMBIN | BIOGEN, INC. (US) | 1991-03-07 | — | — | WO | disclosed |