Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | BCR | P11274 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 6/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 6/20 | 0.39 |
| ▸ | PAK4 | O96013 | 6/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 6/20 | 0.39 |
| ▸ | CLK2 | P49760 | 6/20 | 0.39 |
| ▸ | PRKX | P51817 | 6/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742531 | 0.87 | ABL1 (0.54) | ABL1BCRAURKATNIKSNCA | |
| SCHEMBL4633253 | 0.86 | HDAC1 (0.51) | ABL1BCRAURKAHDAC1HDAC6 | |
| SCHEMBL742638 | 0.85 | ABL1 (0.74) | ABL1BCRAURKAHDAC1MAPT | |
| SCHEMBL740623 | 0.85 | ABL1 (0.72) | ABL1BCRAURKAHDAC1TNIK | |
| SCHEMBL743719 | 0.85 | ABL1 (0.55) | ABL1BCRAURKAHDAC1HDAC6 | |
| SCHEMBL741183 | 0.85 | ABL1 (0.76) | ABL1BCRAURKAHDAC1MAPT | |
| SCHEMBL740752 | 0.85 | ABL1 (0.76) | ABL1BCRAURKAHDAC1MAPT | |
| SCHEMBL739604 | 0.85 | ABL1 (0.66) | ABL1BCRAURKAHDAC1HDAC6 | |
| SCHEMBL740292 | 0.84 | AURKA (0.55) | ABL1BCRAURKAHDAC6KMT2A | |
| SCHEMBL743125 | 0.84 | ABL1 (0.65) | ABL1BCRAURKAHDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |