Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 14/20 | 0.63 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10460358 | 0.98 | CHRM3 (0.61) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL455554 | 0.89 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Bromide SCHEMBL10652839 | 0.87 | CHRM3 (0.57) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL7414071 | 0.85 | CHRM3 (0.50) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10460428 | 0.77 | CHRM3 (1.00) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Gaboxadol SCHEMBL5533785 | 0.77 | CHRM3 (0.46) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Gaboxadol SCHEMBL247815 | 0.77 | CHRM3 (0.46) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10460426 | 0.76 | CHRM3 (0.97) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL5725425 | 0.76 | KMT2A (0.44) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Gaboxadol SCHEMBL23851948 | 0.76 | CHRM3 (0.45) | CHRM3CHRM5CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000338-B1 | ISOXAZOLO(5,4-C)PYRIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | H.Lundbeck & Co., A/S (DK) | 1981-11-25 | — | — | EP | disclosed |
| US-4301287-A | FOR TREATMENT OF PSYCHOLOGICAL AND NERVOUS SYSTEM DISORDERS | H. LUNDBECK & CO. A/S (DK) | 1981-11-17 | — | — | US | disclosed |
| US-4278676-A | NERVOUS SYSTEM DISORDERS, CYCLIZATION, HYDROLYSIS | H. LUNDBECK & CO. A/S (DK) | 1981-07-14 | — | — | US | disclosed |
| EP-0000338-A2 | Isoxazolo(5,4-c)pyridine derivatives, their preparation and pharmaceutical compositions containing them | H.Lundbeck & Co., A/S (DK) | 1979-01-24 | — | — | EP | disclosed |