Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | TLR4 | O00206 | 2/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.54 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411916 | 0.92 | ADRB2 (0.63) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7410037 | 0.87 | TLR4 (0.58) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7410151 | 0.86 | ADRB2 (0.51) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7416746 | 0.85 | ADRB2 (0.44) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7410117 | 0.85 | ADRB2 (0.51) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7411213 | 0.85 | ADRB2 (0.53) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7410178 | 0.84 | ADRB2 (0.49) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7403482 | 0.83 | ADRB2 (0.48) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7412052 | 0.83 | ADRB2 (0.48) | ADRB2DRD2TLR4HTR1ASLC6A4 | |
| SCHEMBL7406337 | 0.83 | ADRB2 (0.51) | ADRB2DRD2TLR4HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4503067-A | HYPOTENSIVE, ANGINA PECTORIS | BOEHRINGER MANNHEIM GMBH (DE) | 1985-03-05 | — | — | US | disclosed |
| EP-0004920-A1 | Derivatives of carbazolyl-4-oxypropanolamine, methods for their preparation and medicines containing them | Roche Diagnostics GmbH (DE) | 1979-10-31 | — | — | EP | disclosed |