Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 5/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417404 | 0.83 | IRAK4 (0.42) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7414715 | 0.82 | IRAK4 (0.41) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7404130 | 0.82 | IRAK4 (0.41) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7416134 | 0.82 | CHRNB4 (0.54) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7411925 | 0.81 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7409488 | 0.75 | CHRNB2 (0.55) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7408472 | 0.74 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7405400 | 0.73 | IRAK4 (0.36) | CHRNB4CHRNA3IRAK4 | |
| SCHEMBL7409579 | 0.72 | CHRNB2 (0.44) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4 | |
| SCHEMBL7411589 | 0.69 | CHRNB2 (0.57) | CHRNB4CHRNA3CHRNB2CHRNA4IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |