Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413396 | 0.88 | ADORA3 (0.43) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL7413902 | 0.86 | ADORA3 (0.50) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL7408875 | 0.84 | ADORA3 (0.52) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL7409538 | 0.75 | ADORA3 (0.50) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL7411802 | 0.73 | ADORA3 (0.52) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL7415475 | 0.72 | MAPT (0.49) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL30273066 | 0.67 | CHRNA7 (0.55) | MAPTADORA3KDM4EALDH1A1MEN1 | |
| SCHEMBL13025156 | 0.67 | MAP3K11 (0.60) | KDM4EMEN1KMT2ACYP1A2PARP1 | |
| SCHEMBL14355018 | 0.67 | KDM4E (0.57) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL28132803 | 0.65 | MAPT (0.71) | MAPTKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908932-A | Certain pyrroloquinolinones; a new class of GABA brain receptor | NEUROGEN CORPORATION (US) | 1999-06-01 | — | — | US | disclosed |
| US-5604235-A | DIAGNOSIS AND TREATMENT OF ANXIETY, SLEEP AND SEIZURE DISORDERS, BENZODIAZEPINE OVERDOSE; ENHANCEMENT OF MEMORY | NEUROGEN CORPORATION (US) | 1997-02-18 | — | — | US | disclosed |
| US-5243049-A | Gamma-aminobutyric acid antagonist | NEUROGEN CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |