Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7099709 | 0.99 | HTR1A (0.55) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL4891407 | 0.81 | HTR1A (0.63) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL4888785 | 0.81 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7099058 | 0.80 | HTR1A (0.55) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL4890097 | 0.79 | HTR1A (0.73) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7098770 | 0.78 | HTR1A (0.72) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL13533146 | 0.76 | HTR1A (0.62) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL4888935 | 0.76 | HTR1A (0.63) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL4891127 | 0.75 | HTR1A (0.65) | HTR1ADRD2HTR2ASLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL7099408 | 0.75 | HTR1A (0.62) | HTR1ADRD2HTR2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281309-B1 | PIPERAZINYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1991-12-27 | — | — | EP | claimed |
| EP-0281309-A1 | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1988-09-07 | — | — | EP | claimed |
| EP-0281309-B1 | PIPERAZINYL-HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 1991-12-27 | — | — | EP | disclosed |
| US-4883795-A | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1989-11-28 | — | — | US | disclosed |
| US-4831031-A | Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity | PFIZER INC. (US) | 1989-05-16 | — | — | US | disclosed |
| EP-0281309-A1 | Piperazinyl-heterocyclic compounds | PFIZER INC. (US) | 1988-09-07 | — | — | EP | disclosed |