Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.51 |
| ▸ | PPARA | Q07869 | 11/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8450043 | 0.87 | PPARG (0.51) | PPARGPPARASMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL12220660 | 0.83 | SMN1; SMN2 (0.49) | PPARGPPARASMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL6765131 | 0.83 | MIF (0.48) | PPARGPPARASMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL14378432 | 0.83 | MIF (0.48) | PPARGPPARASMN1; SMN2TSHRCYP1A2 | |
| SCHEMBL2891961 | 0.83 | PPARG (0.67) | PPARGPPARASMN1; SMN2 | |
| SCHEMBL13433920 | 0.83 | ALDH1A1 (0.45) | PPARGPPARASMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL21129084 | 0.82 | CYP1A2 (0.56) | PPARGPPARATSHRKLK7CYP1A2 | |
| SCHEMBL25997018 | 0.82 | CYP1A2 (0.56) | PPARGPPARATSHRKLK7CYP1A2 | |
| SCHEMBL8449775 | 0.82 | PPARG (0.53) | PPARGPPARASMN1; SMN2POLB | |
| SCHEMBL9128983 | 0.82 | PPARG (0.74) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |