Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568261 | 0.97 | CYP1A2 (0.48) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL7410546 | 0.83 | TDP1 (0.45) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL2994232 | 0.82 | CYP1A2 (0.50) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL30410464 | 0.82 | CYP1A2 (0.50) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL19329660 | 0.81 | CYP1A2 (0.69) | CYP1A2MAPTTDP1PDK1ALDH1A1 | |
| SCHEMBL6973093 | 0.81 | CYP1A2 (0.49) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL2989578 | 0.80 | CYP1A2 (0.69) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL27707665 | 0.80 | TDP1 (0.49) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL2989584 | 0.80 | CYP1A2 (0.69) | CYP1A2MAPTTDP1ATMPDK1 | |
| SCHEMBL7594106 | 0.79 | CYP1A2 (0.50) | CYP1A2MAPTTDP1ATMPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |