Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.67 |
| ▸ | DRD2 | P14416 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6938937 | 0.89 | KCNH2 (0.76) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL9041083 | 0.87 | KCNH2 (0.80) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL5988317 | 0.83 | KCNH2 (0.88) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL4528457 | 0.82 | KCNH2 (1.00) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL4703805 | 0.81 | CHKA (0.53) | DRD2DRD4DRD3HRH1 | |
| SCHEMBL10684565 | 0.80 | CYP2D6 (0.79) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL11762555 | 0.80 | KCNH2 (0.69) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL3453669 | 0.80 | DRD2 (1.00) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL11751661 | 0.80 | KCNH2 (0.69) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 | |
| SCHEMBL12605630 | 0.80 | KCNH2 (0.69) | KCNH2SIGMAR1DRD2HTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273976-A | Ocular hypotensive agents | SANKYO COMPANY, LIMITED (JP) | 1993-12-28 | — | — | US | disclosed |
| US-5175161-A | Treatment of glaucoma | SANKYO COMPANY, LIMITED (JP) | 1992-12-29 | — | — | US | disclosed |
| EP-0391721-A2 | Ocular hypotensive agents | Sankyo Company Limited (JP) | 1990-10-10 | — | — | EP | disclosed |