Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.45 |
| ▸ | PDE4A | P27815 | 7/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28279542 | 0.86 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7866895 | 0.85 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7865357 | 0.83 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL25111149 | 0.77 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL28242988 | 0.76 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL29723277 | 0.76 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL16650722 | 0.76 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7421380 | 0.75 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL22713890 | 0.73 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL30352593 | 0.73 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5449687-A | 4-phenyl-1,2-cyclohexyl derivatives and anti-inflammatory compositions and methods thereof | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0633771-A4 | COMPOUNDS. | — | 1995-02-22 | — | — | EP | disclosed |
| EP-0633771-A1 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-18 | — | — | EP | disclosed |
| WO-1993019720-A2 | COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | disclosed |