Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.49 |
| ▸ | PDE4A | P27815 | 11/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7865357 | 0.89 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7792800 | 0.87 | CASP1 (0.42) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7424415 | 0.86 | CASP1 (0.50) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7413446 | 0.85 | CASP1 (0.51) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7532617 | 0.84 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL28279542 | 0.82 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7421932 | 0.81 | CASP1 (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL28242988 | 0.79 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CABCB11 | |
| SCHEMBL7858782 | 0.77 | CASP1 (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8677454 | 0.77 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636025-B1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC OR INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORP (US) | 2001-07-18 | — | — | EP | disclosed |
| US-5811455-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-22 | — | — | US | disclosed |
| US-5631286-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| US-5449686-A | Compounds useful for treating allergic or inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |