Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 10/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | ICMT | O60725 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7412090 | 0.96 | ITGB3 (0.47) | ITGB3ITGA2BTYMSMEN1KMT2A | |
| SCHEMBL7412949 | 0.90 | ITGB3 (0.55) | ITGB3ITGA2BMEN1KMT2AL3MBTL1 | |
| SCHEMBL7412096 | 0.88 | MEN1 (0.43) | ITGB3ITGA2BMEN1KMT2AL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL7414945 | 0.86 | ITGB3 (0.52) | ITGB3ITGA2BL3MBTL1ADAMTS4MMP2 | |
| SCHEMBL7409585 | 0.86 | ITGB3 (0.61) | ITGB3ITGA2BADAMTS4MMP13ITGAV | |
| SCHEMBL7414200 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BITGAVMMP2MMP9 | |
| SCHEMBL7412198 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BITGAVMMP2MMP9 | |
| SCHEMBL7702396 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BMMP13ITGAVMMP2 | |
| SCHEMBL7415995 | 0.86 | ITGB3 (0.51) | ITGB3ITGA2BITGAVMMP2MMP9 | |
| SCHEMBL7695355 | 0.86 | BCL2 (0.49) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |