Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.48 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.48 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409563 | 1.00 | CHRNB2 (0.48) | CHRNB2CHRNB4CHRNA3CHRNA5CHRNA2 | |
| SCHEMBL7408579 | 0.86 | — | — | |
| SCHEMBL7402668 | 0.85 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA5CHRNA4 | |
| SCHEMBL7407732 | 0.85 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA5CHRNA4 | |
| SCHEMBL7406760 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA5CHRNA4 | |
| SCHEMBL8552509 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1220341 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1220344 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL12375141 | 0.77 | CHRNB2 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7416924 | 0.76 | CHRNB2 (0.37) | CHRNB2CHRNA2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047690-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999032480-A1 | HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 1999-07-01 | — | — | WO | disclosed |