Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Rimcazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.85 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.85 |
| ▸ | MEN1 | O00255 | 2/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.85 |
| ▸ | TP53 | P04637 | 1/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.85 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | HTR2A | P28223 | 1/20 | 0.85 |
| ▸ | HTR2C | P28335 | 1/20 | 0.85 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
| ▸ | HTR2B | P41595 | 1/20 | 0.85 |
| ▸ | HTT | P42858 | 1/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.81 |
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rimcazole SCHEMBL7414118 | 1.00 | SIGMAR1 (0.85) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL29710924 | 0.92 | SIGMAR1 (1.00) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL31395408 | 0.92 | SIGMAR1 (1.00) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL99084 | 0.92 | SIGMAR1 (1.00) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL3237432 | 0.92 | SIGMAR1 (1.00) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL7406436 | 0.91 | SIGMAR1 (0.79) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL7416509 | 0.91 | SIGMAR1 (0.79) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL7406439 | 0.91 | SIGMAR1 (0.79) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL6257536 | 0.91 | SIGMAR1 (0.97) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 | |
| Rimcazole SCHEMBL122161 | 0.91 | SIGMAR1 (0.97) | SIGMAR1SCARB1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400383-A | 9-(3-(3,5-CIS-DIMETHYLPIPERAZINO/PROPYL)CARBAZOLE | BURROUGHS WELLCOME CO. (US) | 1983-08-23 | — | — | US | disclosed |
| US-4379160-A | Carbazole compounds and medicinal use thereof | BURROUGHS WELLCOME CO. (US) | 1983-04-05 | — | — | US | disclosed |
| EP-0012208-B1 | 9-(3-(3,5-CIS-DIMETHYLPIPERAZINO)PROPYL)-CARBAZOLE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-01-26 | — | — | EP | disclosed |
| EP-0012208-A2 | 9-(3-(3,5-cis-Dimethylpiperazino)propyl)-carbazole, its preparation and pharmaceutical compositions containing it | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-06-25 | — | — | EP | disclosed |