SCHEMBL7414213

SCHEMBL7414213

O=C(N[C@@H](CCc1ccccc1)S(=O)(=O)c1ccccc1)C(Cc1ccccc1)NC(=O)N1CCOCC1

nearest known ligand 0.70

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CTSL P07711 9/20 0.70
CTSB P07858 8/20 0.70
CTSS P25774 11/20 0.67
CTSK P43235 3/20 0.57
CTSH P09668 1/20 0.57
CTSC P53634 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8696034 1.00 CTSL (0.70) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7414216 1.00 CTSL (0.70) CTSLCTSBCTSSCTSKCTSH
SCHEMBL8696030 1.00 CTSL (0.70) CTSLCTSBCTSSCTSKCTSH
SCHEMBL8159870 0.87 CTSL (0.66) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7414175 0.84 CTSL (0.67) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7414172 0.84 CTSL (0.67) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7349443 0.82 CTSL (1.00) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7349450 0.82 CTSL (1.00) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7355588 0.82 CTSL (1.00) CTSLCTSBCTSSCTSKCTSH
SCHEMBL7349448 0.82 CTSL (1.00) CTSLCTSBCTSSCTSKCTSH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5776718-A Reversible protease inhibitors ARRIS PHARMACEUTICAL CORPORATION (US) 1998-07-07 US disclosed
EP-0817778-A1 REVERSIBLE PROTEASE INHIBITORS ARRIS PHARMACEUTICAL CORPORATION (US) 1998-01-14 EP disclosed
WO-1996030353-A1 REVERSIBLE PROTEASE INHIBITORS ARRIS PHARMACEUTICAL CORPORATION (US) 1996-10-03 WO disclosed