Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414359 | 1.00 | HRH3 (0.44) | HRH3OPRM1OPRL1LTA4HMAOB | |
| SCHEMBL7414398 | 0.87 | MAOB (0.35) | HRH3MAOBKDM2BHTR2AHTR2C | |
| SCHEMBL7422060 | 0.87 | HTR2A (0.37) | MAOBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7414389 | 0.87 | MAOB (0.35) | HRH3MAOBKDM2BHTR2AHTR2C | |
| SCHEMBL7422054 | 0.87 | HTR2A (0.37) | MAOBHTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL7407659 | 0.86 | SIGMAR1 (0.46) | HRH3OPRM1LTA4HHTR2AHTR2C | |
| SCHEMBL7410376 | 0.86 | SIGMAR1 (0.46) | HRH3OPRM1LTA4HHTR2AHTR2C | |
| SCHEMBL7414839 | 0.86 | SIGMAR1 (0.46) | HRH3OPRM1LTA4HHTR2AHTR2C | |
| SCHEMBL6857578 | 0.86 | SIGMAR1 (0.41) | SIGMAR1 | |
| SCHEMBL6859020 | 0.86 | SIGMAR1 (0.41) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734379-B1 | 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | PARKE DAVIS (FR) | 2001-03-07 | — | — | EP | claimed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | claimed |
| EP-0995436-A2 | Ligands for sigma receptors and their therapeutical applications | PARKE-DAVIS (FR) | 2000-04-26 | — | — | EP | disclosed |
| US-6013656-A | PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS; NERVOUSSYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| US-5849760-A | 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1998-12-15 | — | — | US | disclosed |
| EP-0734379-A1 | NOVEL 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | INSTITUT DE RECHERCHE JOUVEINAL (I.R.J) (FR) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995015948-A1 | NOVEL 2-ARYLALKENYL-AZACYCLOALKANE DERIVATIVES AS SIGMA RECEPTOR LIGANDS, PREPARATION METHOD THEREFOR AND THERAPEUTICAL USE THEREOF | INSTITUT DE RECHERCHE JOUVEINAL (FR) | 1995-06-15 | — | — | WO | disclosed |