Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.61 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.59 |
| ▸ | TACR1 | P25103 | 2/20 | 0.53 |
| ▸ | CTSB | P07858 | 2/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418088 | 1.00 | TRPM8 (0.61) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL7245549 | 1.00 | TRPM8 (0.61) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL6350990 | 1.00 | TRPM8 (0.61) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL7430937 | 1.00 | TRPM8 (0.61) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL11407932 | 0.95 | TRPM8 (0.56) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL11414657 | 0.95 | TRPM8 (0.56) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL11422143 | 0.93 | PPARA (0.56) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL7435563 | 0.93 | PPARA (0.56) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL11419293 | 0.92 | TRPM8 (0.57) | TRPM8CTRB1TACR1CTSBCTSL | |
| SCHEMBL7433785 | 0.90 | ATM (0.63) | TRPM8CTRB1CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4240975-A | USED AS ENZYME INHIBITOR, ANTIFERTILITY AGENT, AND ENHANCES THE ANTITUMOR EFFECT OF BLEOMYCIN | ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) | 1980-12-23 | — | — | US | claimed |
| CN-112125951-A | Impurities in ubenimex bulk drug and preparation method thereof | 深圳万乐药业有限公司 | 2020-12-25 | — | — | CN | disclosed |
| CN-106117075-B | Novel ubenimex recrystallization method | 上海信谊万象药业股份有限公司 | 2020-06-12 | — | — | CN | disclosed |
| CN-109053782-B | Multifunctional targeting immune micromolecule anticancer drug Bestazomib citrate and preparation method and application thereof | 潍坊博创国际生物医药研究院 | 2020-01-17 | — | — | CN | disclosed |
| EP-0364344-B1 | Novel peptidase inhibitors | MERRELL PHARMA INC (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5736520-A | INHIBITING CALPAIN BY ADMINISTERING A DIPEPTIDE OF THE FORMULA BENZYLCARBONYLOXYVAL-NH-CH(-R2)-CHO WHERE R2 IS THE SIDE CHAIN OF PHE; ANTICARCINOGENIC,-ARTHRITIC AND CARDIOTONIC AGENTS; COAGULANTS; STROKE | MERRELL PHARMACEUTICALS INC. (US) | 1998-04-07 | — | — | US | disclosed |
| WO-1993013066-A1 | CYCLIC AMIDES OF 3-AMINO-2-HYDROXY-CARBOXYLIC ACIDS AS HIV-PROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-07-08 | — | — | WO | disclosed |
| EP-0364344-A2 | Novel peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |