Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 16/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | F7 | P08709 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.46 |
| ▸ | F3 | P13726 | 2/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7418427 | 0.93 | MRGPRX4 (0.52) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL5882826 | 0.87 | MRGPRX4 (0.49) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL5883573 | 0.86 | MRGPRX4 (0.54) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL5883476 | 0.84 | F10 (0.63) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 | |
| SCHEMBL7143676 | 0.77 | F2 (0.57) | MRGPRX4SMN1; SMN2F2F10PRSS1 | |
| SCHEMBL7415363 | 0.77 | F10 (0.49) | F2F10PRSS1F7PRSS2 | |
| SCHEMBL7414799 | 0.76 | F10 (0.50) | F2F10PRSS1F7PRSS2 | |
| SCHEMBL5882703 | 0.75 | F10 (0.54) | F2F10PRSS1F7PRSS2 | |
| SCHEMBL5882886 | 0.73 | F7 (0.81) | MRGPRX4SMN1; SMN2F2F10PRSS1 | |
| SCHEMBL5882835 | 0.72 | MRGPRX4 (0.54) | MRGPRX4SMN1; SMN2TP53PKMNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149069-A1 | PHENYLGLYCINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-31 | — | — | EP | disclosed |
| WO-2000035858-A1 | PHENYLGLYCINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |