Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | PREP | P48147 | 4/20 | 0.59 |
| ▸ | KLK7 | P49862 | 1/20 | 0.58 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14893288 | 0.89 | TSHR (0.64) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL847403 | 0.89 | TSHR (0.64) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL16272917 | 0.86 | FKBP1A (0.66) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL7326760 | 0.86 | FKBP1A (0.66) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL8280028 | 0.86 | FKBP1A (0.66) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL5764209 | 0.86 | FKBP1A (0.66) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL5525089 | 0.85 | PREP (0.67) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL630112 | 0.85 | PREP (0.67) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL4724457 | 0.85 | PREP (0.67) | TSHRL3MBTL1KDM4ELMNAPREP | |
| SCHEMBL19360224 | 0.85 | TSHR (0.59) | TSHRL3MBTL1KDM4ELMNAPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | claimed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | claimed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |
| WO-1993013066-A1 | CYCLIC AMIDES OF 3-AMINO-2-HYDROXY-CARBOXYLIC ACIDS AS HIV-PROTEASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-07-08 | — | — | WO | disclosed |