SCHEMBL7414853

SCHEMBL7414853

CC(=O)Nc1cncc(OC(C)[C@@H]2CCCN2)c1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.39
CREBBP Q92793 1/20 0.39
GHSR Q92847 8/20 0.39
RORC P51449 1/20 0.38
DPP4 P27487 3/20 0.38
PREP P48147 1/20 0.38
CHRNB2 P17787 2/20 0.37
CHRNA4 P43681 2/20 0.37
DPP8 Q6V1X1 1/20 0.36
CHRNA1 P02708 1/20 0.36
CHRNG P07510 1/20 0.36
CHRNB1 P11230 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRND Q07001 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8507375 0.82 CHRNB4 (0.36) CHRNB4CHRNA3
SCHEMBL8551354 0.79 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7412549 0.78 CHRNB2 (0.35) BRD4CREBBPCHRNB2CHRNA4CHRNA1
SCHEMBL7406929 0.77 CHRNB4 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7668971 0.77 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL7411409 0.77 CHRNB4 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL4962971 0.77 CHRNB2 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL6233084 0.77 CHRNB2 (0.40) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL8552672 0.76 BRD4 (0.34) BRD4CREBBPCHRNB2CHRNA4CHRNA1
SCHEMBL8507735 0.76 CHRNB2 (0.34) CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047690-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION Abbott Laboratories (US) 2000-11-02 EP disclosed
WO-1999032480-A1 HETEROCYCLIC ETHER AND THIOETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LABORATORIES (US) 1999-07-01 WO disclosed