Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BMP1 | P13497 | 1/20 | 0.43 |
| ▸ | MMP10 | P09238 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 5/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412021 | 1.00 | MMP7 (0.48) | MMP7RAB9ABMP1MMP10MMP9 | |
| SCHEMBL7418075 | 0.89 | MMP7 (0.55) | MMP7RAB9AMMP10MMP9PSMB5 | |
| SCHEMBL7418330 | 0.89 | MMP7 (0.58) | MMP7BMP1MMP10MMP9ADAM17 | |
| SCHEMBL7416941 | 0.88 | MMP7 (0.55) | MMP7BMP1MMP10MMP9 | |
| SCHEMBL7417269 | 0.88 | MMP7 (0.55) | MMP7BMP1MMP10MMP9CCR2 | |
| SCHEMBL7407679 | 0.83 | MMP7 (0.56) | MMP7RAB9ABMP1MMP10MMP9 | |
| SCHEMBL7415732 | 0.83 | MMP7 (0.56) | MMP7RAB9AMMP10MMP9PSMB5 | |
| SCHEMBL7416093 | 0.79 | MMP7 (0.52) | MMP7RAB9AMMP10MMP9PSMB5 | |
| SCHEMBL7414539 | 0.79 | MMP7 (0.55) | MMP7MMP10MMP9PSMB5 | |
| SCHEMBL7418545 | 0.79 | MMP7 (0.55) | MMP7BMP1MMP10MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |