Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741490 | 1.00 | HRH1 (0.42) | HRH1KCNH2CYP2D6CHRM1CFD | |
| SCHEMBL741010 | 0.89 | HRH1 (0.50) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL739699 | 0.89 | HRH1 (0.50) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741047 | 0.89 | HRH1 (0.50) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741011 | 0.89 | HRH1 (0.50) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL739630 | 0.89 | KCNH2 (0.44) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL762869 | 0.89 | KCNH2 (0.48) | HRH1KCNH2CYP2D6CHRM1MCHR1 | |
| SCHEMBL741582 | 0.89 | TP53 (0.44) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL741581 | 0.89 | TP53 (0.44) | HRH1KCNH2CYP2D6CHRM1USP2 | |
| SCHEMBL742589 | 0.89 | KCNH2 (0.48) | HRH1KCNH2CYP2D6CHRM1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | claimed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |