Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 19/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 18/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 4/20 | 0.48 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421664 | 0.95 | ITGAV (0.56) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL5848885 | 0.86 | ITGAV (0.52) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL8479069 | 0.83 | ITGAV (0.57) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL5796484 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL30336058 | 0.81 | ITGAV (0.56) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL6896978 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL13833866 | 0.81 | ITGAV (0.56) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL4716711 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL22497890 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGA2BITGB5ITGB6 | |
| SCHEMBL8347928 | 0.81 | ITGAV (0.58) | ITGAVITGB3ITGA2BITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880511-A4 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-06-16 | — | — | EP | disclosed |
| EP-0880511-A1 | INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997026250-A1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-07-24 | — | — | WO | disclosed |