Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 16/20 | 0.52 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.52 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.52 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849909 | 0.92 | ITGAV (0.48) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL7414995 | 0.86 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL6896978 | 0.84 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL8326050 | 0.83 | ITGAV (0.39) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL19514883 | 0.82 | ITGAV (0.39) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL4716711 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL5796484 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL22497890 | 0.81 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL13833866 | 0.81 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB5ITGB8 | |
| SCHEMBL30336058 | 0.81 | ITGAV (0.56) | ITGAVITGB3ITGB6ITGB5ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115596-B2 | Thiazole compounds as integrin receptor antagonists derivatives | PHARMACIA CORPORATION (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1592421-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | Pharmacia Corporation (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1572690-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | Pharmacia Corporation (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050043344-A1 | Heteroarylalkanoic acids as integrin receptor antagonists derivatives | PHARMACIA CORPORATION | 2005-02-24 | — | — | US | disclosed |
| US-20050004189-A1 | Thiazole compounds as integrin receptor antagonists derivatives | PHARMACIA CORPORATION | 2005-01-06 | — | — | US | disclosed |
| WO-2004058760-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058760-A1 | THIAZOLE COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058254-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058254-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | disclosed |
| US-6268378-B1 | TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH. | MERCK & CO., INC. | 2001-07-31 | — | — | US | disclosed |
| US-6066648-A | USEFUL IN INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, AND INHIBITING VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, ATHEROSCLEROSIS, INFLAMMATION, VIRAL DISEASE, AND TUMOR GROWTH | MERCK & CO., INC. (US) | 2000-05-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043344-A1 | Heteroarylalkanoic acids as integrin receptor antagonists derivatives | ITGA5, ITGAV, ITGA6 | ITGAV 2/4885ITGB3 6/4885ITGB6 5/4885 |
| US-20050004189-A1 | Thiazole compounds as integrin receptor antagonists derivatives | ITGA5, ITGB5, ITGAL | ITGAV 5/4885ITGB3 4/4885ITGB6 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.