Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 10/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4451560 | 0.86 | F2 (0.65) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7412218 | 0.85 | ITK (0.41) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7410856 | 0.80 | ITK (0.38) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL8032174 | 0.80 | F2 (0.58) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7413176 | 0.79 | F2 (0.40) | F2F10PLGDPP7ITK | |
| SCHEMBL7418277 | 0.78 | CHRNA7 (0.44) | DPP7ITK | |
| SCHEMBL7415075 | 0.78 | F2 (0.74) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL7096708 | 0.77 | F2 (0.40) | F2F10PLGDPP7ITK | |
| SCHEMBL7096731 | 0.72 | F2 (0.37) | F2F10PLGDPP7ITK | |
| SCHEMBL7101549 | 0.72 | F2 (0.38) | F2F10PLGDPP7ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-B1 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-12-11 | — | — | EP | disclosed |
| US-6248770-B1 | CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-06-19 | — | — | US | disclosed |