Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 11/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412635 | 0.75 | LCK (0.43) | STK17BSTK17ALCK | |
| SCHEMBL7411640 | 0.74 | MAPKAPK2 (0.34) | STK17BSTK17ALCKPTGDR2HPGD | |
| SCHEMBL7411293 | 0.72 | ATR (0.38) | PTGDR2SREBF2 | |
| SCHEMBL7411279 | 0.71 | SYK (0.36) | STK17BSTK17AHPGDSREBF2MAPKAPK2 | |
| SCHEMBL7419909 | 0.70 | METAP1 (0.39) | HPGDSREBF2CNR2 | |
| SCHEMBL29598429 | 0.69 | LMNA (0.43) | LCKBRD4 | |
| SCHEMBL20087958 | 0.68 | ATR (0.44) | STK17BSTK17ALCKMAPKAPK2 | |
| SCHEMBL21306838 | 0.68 | LCK (0.51) | LCK | |
| SCHEMBL7410155 | 0.67 | LMNA (0.39) | POLBCNR2 | |
| SCHEMBL31248792 | 0.66 | STK17B (0.43) | STK17BSTK17ALCKBRD4MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |